Role of Immunity, Epigenome and Microbiome in Childhood Asthma Development

Binational Early Asthma and Microbiome Study (BEAMS)

This multi-PI study examines the impact of environmental (microbial) exposures on childhood asthma across the US/Mexico border. The Vercelli laboratory is assessing whether exposure to distinct environmental and endogenous microbes differentially shapes the asthma trajectory in US and Mexican children and relevant mouse models.

Funding: P01AI148104

This study shows that maternal prenatal immunity, neonatal trained immunity, and early airway microbiota shape childhood asthma development.
PMID: 35841380

Funding: R21AI133765

Ashley N Michael, Oksana PivnioukPeace C EzehSunil BanskarSeongmin HahnAvery DeVriesKathryn O’ConnellVadim Pivniouk, Donata Vercelli. Administration of a Bacterial Lysate to the Airway Compartment Is Sufficient to Inhibit Allergen-Induced Lung Eosinophilia in Germ-free Mice. Journal of Leukocyte Biology. March 2024. Online ahead of print. PMID: 38470858

Microbial Products in Asthma Protection

This study shows the cellular and molecular mechanisms through which OM-85, a lysate of several bacterial strains commonly found in the human airways, provides protection against allergic asthma.

PMID: 34560105

This work demonstrates that the OM-85 bacterial lysate suppresses SARS-CoV-2 infection of human epithelial cells by downregulating the expression of the SARS-CoV-2 receptor ACE2.

PMID: 34902435

Funding: OM Pharma, Geneva, Switzerland

Asthma Protection: Mechanisms and Agents

Role of γδ17 T Cells in Asthma Protection by Amish Farm Exposure

This study is using biochemical approaches and mouse models to dissect the environmental factors and host mechanisms responsible for asthma protection among traditional Amish dairy farmers.
PMID: 27518660

This project uses multiple and complementary in vivo approaches to explore the role of γδ17 T cells in the asthma-protective effects of farm dust exposure.

Funding: R21AI144722

Marques dos Santos M., V. Pivniouk, B. Rankl, A. Walker, G. Pagani, N. Hertkorn, P. Schmitt-Kopplin, C. Müller, F. Bracher, J. Merl-Pham, S.M. Hauck, M. Schloter, A.N. Michael, D. Anderson, L. Honeker, J. Gozdz, O. Pivniouk, M. Holbreich, F.D. Martinez, S.A. Snyder, E. von Mutius and D. Vercelli. Asthma-protective agents in dust fron traditional farm environments. J. Allergy Clin. Immunol.(2023)

PMID: 37271318

Innate Immunity and Viral Infection in Asthma

This multi-PI Asthma and Airway Disease Clinical Research Center program investigates how innate immune pathways protect from asthma during viral infections. The Vercelli laboratory is examining the role of type 2 cytokines in protection against SARS-CoV-2 infection.

PMID: 32422146

Funding: U19AI125357