Selected Publications (2016- )

Yuhan Xing, Miranda Sin-Man Tsang, Zhaowei Yang, Maggie Haitian Wang, Vadim Pivniouk, Agnes Sze-Yin Leung, Ting-Fan Leung, Marjut Roponen, Bianca Schaub, Donata Vercelli, Chun-Kwok Wong, Jing Li, Gary Wing-Kin Wong. Immune modulation by rural exposures and allergy protection. Pediatr Allergy Immunol. Feb. 2024. PMID: 38351891

Ashley N Michael, Oksana PivnioukPeace C EzehSunil BanskarSeongmin HahnAvery DeVriesKathryn O’ConnellVadim Pivniouk, Donata Vercelli. Administration of a Bacterial Lysate to the Airway Compartment Is Sufficient to Inhibit Allergen-Induced Lung Eosinophilia in Germ-free Mice. Journal of Leukocyte Biology. March 2024. Online ahead of print. PMID: 38470858

Marques dos Santos M., V. Pivniouk, B. Rankl, A. Walker, G. Pagani, N. Hertkorn, P. Schmitt-Kopplin, C. Müller, F. Bracher, J. Merl-Pham, S.M. Hauck, M. Schloter, A.N. Michael, D. Anderson, L. Honeker, J. Gozdz, O. Pivniouk, M. Holbreich, F.D. Martinez, S.A. Snyder, E. von Mutius and D. Vercelli. Asthma-protective agents in dust fron traditional farm environments. J. Allergy Clin. Immunol. Volume 152, Issue 3, Sep. 2023, p610-621 PMID: 37271318

Vercelli D. and S.V. Lynch. Interactions between host epigenetics and microbiota: Who does what to whom, when and why? Perspective, J. Allergy Clin. Immunol. 2023 Jun;151(6):1465-1467 PMID: 36720286

Pivniouk V. and Vercelli D. The OM-85 bacterial lysate: A new tool against SARS-CoV-2? Multidiscip. Respir. Med. 2023 18:906
PMID: 36798954

Vercelli D. From Amish farm dust to bacterial lysates: The long and winding road to protection from allergic disease. Seminars in Immunology, Volume 68, July 2023. doi: 10.1016/j.smim.2023.101779. PMID: 37210851.

Honeker L.K., A. Sharma, A. Walker, J. Gozdz, B. Theriault, K. Patil, J.A. Gimenes Jr., A.N. Michael, V. Pivniouk, C. Igartua, M.M. Stein, M. Holbreich, E. von Mutius, P. Schmitt-Kopplin, C. Ober, J.A. Gilbert and D. Vercelli. Gut microbiota from children raised on traditional Amish farms protect against allergic asthma. (Under revision)

Wheatley L.M., J. Holloway, C. Svanes, M.R. Sears, C. Breton, A.V. Fedulov, E. Nilsson, D Vercelli, H. Zhang, A. Togias and S.H. Arshad. The role of epigenetics in multi-generational transmission of asthma: An NIAID workshop report-based narrative review. Clin. Exp. Allergy 2022 Sep 8. doi: 10.1111/cea.14223.
PMID: 36073598

DeVries, A., K. McCauley, D. Fadrosh, K. Lynch, K.E. Fujimura, D.A. Stern, S.V. Lynch, and D. Vercelli. Maternal prenatal immunity, neonatal trained immunity, and early airway microbiota shape childhood asthma development. Allergy 2022 Jul 16. doi: 10.1111/all.15442.
PMID: 35841380

Pali-Schöll I., R. Bianchini, S.M. Afify, G. Hofstetter, S. Winkler, S. Ahlers, T. Altemeier, H. Mayerhofer, K. Hufnagl, A.D.J. Korath, C. Pranger, R. Widhalm, S. Hann, T. Wittek, A. Kasper-Giebl, L.F. Pacios, F. Roth-Walter, D. Vercelli, E. von Mutius, E. Jensen-Jarolim. Secretory protein beta-lactoglobulin in cattle stable dust may contribute to the allergy-protective farm effect. Clin. Transl. Allergy 12(2):e12125. doi: 10.1002/clt2.12125. eCollection 2022 Feb. PMID: 35169442

Pivniouk V., O. Pivniouk, A. DeVries, J.L. Uhrlaub, A.N. Michael, D. Pivniouk, S.R. VanLinden, M.Y. Conway, S. Hahn, S.P. Malone, P. Ezeh, J.M. Churko, D. Anderson, M. Kraft, J. Nikolich-Zugich and D. Vercelli. The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression. J. Allergy Clin. Immunol. 149:923-933 (2022). PMID: 34902435

Editorial, C. Taube: Bacterial lysates to inhibit allergic airway disease: Are they up to the challenge? J. Allergy Clin. Immunol. 149(3):893-894, 2022

Pivniouk V., J.A. Gimenes-Junior, P. Ezeh, A. Michael, O. Pivniouk, S. Hahn, S.R. VanLinden, S.P. Malone, A. Abidov, D. Anderson, J. Gozdz, A. DeVries, F.D. Martinez, C. Pasquali, and D. Vercelli. Airway administration of a bacterial lysate blocks experimental asthma by targeting dendritic cells and the epithelium/IL-33/ILC2 axis. J. Allergy Clin. Immunol. 149:943-956 (2022). PMID: 34560105

Vercelli D. Microbiota and human allergic diseases: The company we keep. Curr. Opin. Immunol. 72:215-220 (2021). PMID:34182271. PMCID: PMC8578191

Lynch, S.V. and D. Vercelli. Microbiota, epigenetics and trained immunity: Convergent drivers and mediators of the asthma trajectory from pregnancy to childhood. Am. J. Respir. Crit. Care Med. 203:802-808 (2021). PMID:33493428.

Morin A., C.G. McKennan, C.E.T. Pedersen, J. Stokholm, B.L. Chawes, A.M. Malby Schoos, K.A. Naughton, J. Thorsen, M.S. Mortensen, D. Vercelli, U. Trivedi, S.J. Sørensen, H. Bisgaard, D.L. Nicolae, K. Bønnelykke, C. Ober. Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age.  J. Allergy Clin. Immunol. 146:1358-1366 (2020) PMID: 32693091

Pivniouk V., J.A. Gimenes-Jr, L. Honeker and D. Vercelli. The role of innate immunity in asthma development and protection: Lessons from the environment. Clin. Exp. Allergy 50:282-290 (2020). PMID:31581343 (Cover)

Kimura, H, D. Francisco, M. Conway, F.D. Martinez, D. Vercelli, F. Polverino, D. Billheimer, M. Kraft. Type 2 inflammation modulates ACE2 and TMPRSS2 in airway epithelial cells. J. Allergy Clin. Immunol. 146:80-88 (2020) PMID: 32422146

Hrusch CL, MM Stein, J Gozdz, M Holbreich, E von Mutius, D Vercelli, C Ober, AI Sperling. T cell phenotypes are associated with serum IgE levels in Amish and Hutterite children. J. Allergy Clin. Immunol. 144:1391-1401 (2019) PMID:31401285

Vercelli D. Are we what our mothers made us? Lessons from Epigenetics. Editorial, J. Allergy Clin. Immunol. 141:525-526 (2018). PMID:29274413

Rothers J, DA Stern, IC Lohman, A Spangenberg, AL Wright, A DeVries, D Vercelli, M Halonen. Maternal cytokine profiles during pregnancy predict asthma in children of mothers without asthma. Am J Respir Cell Mol Biol. 59: 592-600 (2018) PMID: 29863910

DeVries A. and D Vercelli. The neonatal methylome as a gatekeeper in the trajectory to childhood asthma. Epigenomics 9: 585-593 (2017). PMID: 28322586

DeVries A, G Wlasiuk, SJ Miller, A Bosco, DA Stern, IC Lohman, J Rothers, AC Jones, J Nicodemus-Johnson, MM Vasquez, JA Curtin, A Simpson, A Custovic, DJ Jackson, JE Gern, RF Lemanske, Jr., S Guerra, AL Wright, C Ober, M Halonen, and D Vercelli. Epigenome-wide analysis links SMAD3 methylation at birth to asthma in children of asthmatic mothers. J Allergy Clin Immunol. 140:534-542 (2017) PMID: 28011059

Carr TF, P Beamer, J Rothers, DA Stern, LB Gerald, CB Rosales, Y Ornelas Van Horne, ON Pivniouk, D Vercelli, M Halonen, M Gameros, FD Martinez, A Wright. Prevalence of asthma in school children on the Arizona-Sonora Border. Carr TF, P Beamer, J Rothers, DA Stern, LB Gerald, CB Rosales, Y Ornelas Van Horne, ON Pivniouk, D Vercelli, M Halonen, M Gameros, FD Martinez, A Wright. Prevalence of asthma in school children on the Arizona-Sonora Border. J Allergy Clin Immunol Pract. 5:114-120 (2017) PMID:27544711

Ober C., A.I. Sperling, E. von Mutius and D. Vercelli. Immune development and environment: Lessons from Amish and Hutterite children. Curr. Opin. Immunol. 48:51-60 (2017). PMID:28843541

Stein MM, CL Hrusch, J Gozdz, C Igartua, V Pivniouk, SE Murray, JG Ledford, M Marques dos Santos, RL Anderson, N Metwal­i, JW Neilson, RM Maier, JA Gilbert, M Holbreich, PS Thorne, FD Martinez, E von Mutius, D Vercelli, C Ober, AI Sperling. Innate immunity and asthma risk in Amish and Hutterite farm children. N. Engl. J. Med. 375: 411-421 (2016) PMID: 27518660

Commentaries: Nat. Rev. Immunol. 16: 535 (2016) doi:10.1038/nri.2016.97. Lancet Respir. Med. 4: 774, 2016 doi: 10.1016/S2213-2600(16)30270-3
Editorial: T.A. Chatila: Innate immunity in asthma. PMID: 27518667, PMCID: PMC5037902
Recommended by Faculty of 1000Prime
Recipient of a 2017 Top 10 Clinical Research Achievement Awards, Clinical Research Forum
Recipient of the 2017 Herbert Pardes Clinical Research Excellence Award, Clinical Research Forum

Gozdz J, C Ober and D Vercelli. Innate immunity and asthma risk. N. Engl. J. Med. 375:1898-1899 (2016) PMID:27959651